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Mark Stillman, MD

Mark Stillman, MD, leads the research program and is responsible for the management and integrity of the design, conduct, and reporting of the trials and for managing, monitoring, and ensuring the integrity of any collaborative relationships. He meets with each participant and is involved in every study conducted at Insight Clinical Trials (ICT).

He brings 30+ years of experience in clinical research and clinical treatment involving pain, headache, Alzheimer's disease, and other neuropsychiatric disorders. He is board certified in Neurology/Psychiatry and Internal Medicine.

Prior to joining Insight Clinical Trials in 2019, Stillman spent 25 years at the Cleveland Clinic Foundation where he served as Head, Section of Headache and Pain in the Department of Neurology. There he intimately studied migraine sufferers and the autonomic nervous system which regulates certain body processes, such as blood pressure and the rate of breathing. This system works automatically (autonomously), without a person’s conscious effort.

“Fifteen percent of the U.S. population suffer from migraines. I found it interesting how a person’s autonomic nervous system can be wired a slightly differently and how that impacts their ability to function, to be prone to migraines and other pain disorders,” says Stillman.

He brings the same level of interest to the study of Alzheimer’s disease. And is especially optimistic about the current semaglutide drug study that shows promise in not only slowing the disease process but in also helping in the repair of some of the inflammatory effects of the disease.

Stillman is eager to soon bring post-traumatic stress syndrome (PTSD) trials to ICT. “There is a huge unmet need for drugs that are useful for PTSD,” says Stillman who worked clinically with PTSD patients during his time at the Cleveland Clinic Foundation. “People typically can’t get rid of pain until they have dealt with their PTSD. It is very damaging.”

Dr. Stillman is active with his own research projects and publications on migraines, cluster headaches, Alzheimer’s disease, neuropsychiatric symptoms associated with neurogenerative disease and other topics.

His 40+ years of experience began by earning his Bachelor of Science and M.D. at Northwestern University in Chicago and continued with his medical residency at the University of Cincinnati. Stillman completed his Neurology residency at Harvard Medical School followed by his Neuro-oncology and Pain Fellowships at Memorial Sloan-Kettering Cancer Center in New York City.

His is active in many professional societies and his CV lists accolades including many research awards. Insight Clinical Trials is very pleased to have him as the leader of their research team. He works to create a welcoming, encouraging environment for patients and families to learn more about their diseases and what options are available.

For more information about ICT, visit or call 216-526-1843.

Principal Investigator


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